Dr. Cribb's research program focuses on molecular mechanisms of drug and chemical toxicity in animals and humans, and the pharmacogenetic basis of adverse drug reactions and cancer susceptibility. He is particularly interested in the molecular genetics of species and individual differences in response to drugs and chemicals, with an emphasis on idiosyncratic drug reactions. His work has been funded by the CIHR, the Atlantic Innovation Fund, the Canadian Breast Cancer Research Initiative, and others.
Key words: clinical pharmacology, idiosyncratic drug reactions, molecular toxicology, cytochrome P450, breast cancer
Sample publications (please search Cribb-A* on PubMed for a complete listing):
Cribb AE, Pohl L, Spielberg SP, Leeder JS. Patients with delayed onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins. Journal of Pharmacology and Experimental Therapeutics, 282: 1064-72, 1997.
McCrea J, Cribb AE, Rushmore T, Osborne B, Gillin L, Lo M-W, Waldman S, Bjornsson T, Spielberg S, Goldberg MR. Phenotypic and Genotypic Investigations of a Healthy Volunteer Deficient in the Conversion of Losartan to its Active Metabolite, E-3174. Clin Pharmacol Ther, 64: 348-52, 1999. Gaskill C, Cribb A. Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogs. Can Vet J, 41: 555-558, 2000 Saleh TM, Connell BJ, McQuaid T, Cribb AE. Estrogen-induced neurochemical and electrophysiological changes in the parabrachial nucleus of the male rat. Brain Res, 990: 58-65, 2003 McFarlane D, Donaldson M, Cribb AE. Seasonal and sample handling effects on measurement of plasma α-melanocyte stimulating hormone in horses and ponies. Am J Vet Res 65: 1463-8, 2004
Gaskill C, Miller LM, Mattoon JS, Hoffmann WE, Burton S, Gelens H, Ihle S, Miller J, Shaw D, Cribb AE. Liver histopathology and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital. Vet Pathol, 42: 147-160, 2005.
McFarlane D, Dybdal N, Donaldson M, Miller L, Cribb AE. Nitration and increased alpha synuclein expression associated with dopaminergic neurodegeneration in Equine Pituitary Pars Intermedia Dysfunction (PPID). J of Neuroendocrinology 17: 73-80, 2005. Cribb AE, Peyrou M, S. Muruganandan, Schneider L. The endoplasmic reticulum in drug toxicity. Drug Metabolism Reviews, 37: 405-442, 2005. Cribb AE, Knight J, Dryer D, Guernsey J, Tesch M, Saleh TM. Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiology Biomarkers and Prevention 15(3):551-8., 2006. Peyrou M, Cribb AE. Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines. Toxicol in vitro 21:878-86, 2007. Peyrou M, Cribb AE. Calpain inhibition but not endoplasmic reticulum stress preconditioning protects rat kidneys from p-aminophenol toxicity. Toxicological Sciences, 99: 338-45, 2007. Peyrou M, Cribb AE. Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicological Sciences, 99: 346-53, 2007. McConkey SE, Grant DM, Cribb AE. The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats . J Vet Pharm Ther, 32: 585-595, 2009 Cribb A, Buntain B. Innovation in veterinary medical education: the concept of ‘One World, One Health’ in the curriculum of the Faculty of Veterinary Medicine at the University of Calgary. OEI Scientific and Technical Reviews, 28: 753-762, 2009. Cribb AE, Knight MJ, Guernsey J, Dryer D, Shawwa A, Tesch M, Saleh TM. Influence of CYP17, catechol-O-methyltransferase, and glutathione transferase M1 genetic polymorphisms on breast cancer risk in women on Prince Edward Island. Breast J 17: 24-312011