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Alastair E. Cribb

Submitted by admin on Mon, 01/25/2010 - 12:17pm

Professor, Clinical Pharmacology (CBEM)

Degrees and Board Certification: 


Contact Information: 

+1 (403) 220-4570
TRW 2D02


Alastair Cribb completed his DVM degree at the Western College of Veterinary Medicine in 1984. Following an internship and two years in mixed practice in the Maritimes, he obtained his PhD in pharmacogenetics/clinical pharmacology at the Hospital for Sick Children, University of Toronto in 1991. He followed this with an MRC post-doctoral fellowship at Dalhousie University. He then spent four years in drug safety assessment with Merck & Co. in West Point, PA. In 1996, he joined the Atlantic Veterinary College in Charlottetown as a professor of clinical pharmacology where he spent ten years. He accepted the position of Dean, Faculty of Veterinary Medicine, University of Calgary, in May, 2006. He was previously a CIHR/MRC Scholar, a Canada Research Chair in Comparative Pharmacology and Toxicology, and one of Canada's Top 40 under 40. He was a member of CIHR's Governing Council for five years. Dr. Cribb is a Fellow of the Canadian Academy of Health Sciences.

Teaching : 

Dr. Cribb teaches clinical pharmacology in the DVM program (VM443; VM523) and in the clinical presentations and clinical skills courses.  He also contributes to graduate pharmacology courses.

Research / Scholarly Activities: 

Dr. Cribb's research program focuses on molecular mechanisms of drug and chemical toxicity in animals and humans, and the pharmacogenetic basis of adverse drug reactions and cancer susceptibility. He is particularly interested in the molecular genetics of species and individual differences in response to drugs and chemicals, with an emphasis on idiosyncratic drug reactions.  His work has been funded by the CIHR, the Atlantic Innovation Fund, the Canadian Breast Cancer Research Initiative, and others.

Key words: clinical pharmacology, idiosyncratic drug reactions, molecular toxicology, cytochrome P450, breast cancer

Sample publications (please search Cribb-A* on PubMed for a complete listing): 

Cribb AE, Pohl L, Spielberg SP, Leeder JS.  Patients with delayed onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.  Journal of Pharmacology and Experimental Therapeutics, 282: 1064-72, 1997.

McCrea J, Cribb AE, Rushmore T, Osborne B, Gillin L, Lo M-W, Waldman S, Bjornsson T, Spielberg S, Goldberg MR.  Phenotypic and Genotypic Investigations of a Healthy Volunteer Deficient in the Conversion of Losartan to its Active Metabolite, E-3174.  Clin Pharmacol Ther, 64: 348-52, 1999. Gaskill C, Cribb A.  Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogs. Can Vet J, 41: 555-558, 2000 Saleh TM, Connell BJ, McQuaid T, Cribb AE.  Estrogen-induced neurochemical and electrophysiological changes in the parabrachial nucleus of the male rat.  Brain Res, 990: 58-65, 2003 McFarlane D, Donaldson M, Cribb AE.  Seasonal and sample handling effects on measurement of plasma α-melanocyte stimulating hormone in horses and ponies.  Am J Vet Res 65: 1463-8, 2004

Gaskill C, Miller LM, Mattoon JS, Hoffmann WE, Burton S,  Gelens H, Ihle S, Miller J, Shaw D, Cribb AE. Liver histopathology and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital.  Vet Pathol, 42:  147-160, 2005.

McFarlane D, Dybdal N, Donaldson M, Miller L, Cribb AE. Nitration and increased alpha synuclein expression associated with dopaminergic neurodegeneration in Equine Pituitary Pars Intermedia Dysfunction (PPID).  J of Neuroendocrinology 17:  73-80, 2005. Cribb AE,  Peyrou M, S. Muruganandan, Schneider L.  The endoplasmic reticulum in drug toxicity.  Drug Metabolism Reviews, 37: 405-442, 2005. Cribb AE, Knight J, Dryer D, Guernsey J, Tesch M, Saleh TM.  Role of polymorphic human cytochrome P450 enzymes in estrone oxidation.  Cancer Epidemiology Biomarkers and Prevention 15(3):551-8., 2006. Peyrou M, Cribb AE.   Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines.  Toxicol in vitro 21:878-86, 2007. Peyrou M, Cribb AE.  Calpain inhibition but not endoplasmic reticulum stress preconditioning protects rat kidneys from p-aminophenol toxicity. Toxicological Sciences, 99:  338-45, 2007. Peyrou M, Cribb AE.  Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys.  Toxicological Sciences, 99:  346-53, 2007. McConkey SE, Grant DM, Cribb AE.  The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats .  J Vet Pharm Ther, 32:  585-595, 2009 Cribb A, Buntain B.  Innovation in veterinary medical education:  the concept of ‘One World, One Health’ in the curriculum of the Faculty of Veterinary Medicine at the University of Calgary.  OEI Scientific and Technical Reviews, 28:  753-762, 2009. Cribb AE, Knight MJ, Guernsey J, Dryer D, Shawwa A, Tesch M, Saleh TM.  Influence of CYP17, catechol-O-methyltransferase, and glutathione transferase M1 genetic polymorphisms on breast cancer risk in women on Prince Edward Island.  Breast J 17: 24-312011

Graduate Program Affiliations : 

Veterinary Medical Sciences

Submitted by admin on Tue, 03/09/2010 - 4:54pm

Medical Sciences

Submitted by admin on Tue, 03/09/2010 - 4:57pm

Ed Stafford

Submitted by lbutcher on Tue, 09/13/2011 - 10:27am

Senior Director, Operations

Contact Information: 

+1 (403) 210-7021
TRW 2D04

Jerry Bailey

Submitted by lbutcher on Mon, 11/01/2010 - 11:43am

Associate Dean, Academic
Professor (Large Animal Surgery)
Veterinary Clinical and Diagnostic Sciences (VCDS)

Contact Information: 

+1 (403) 210-7654
TRW 2E10

John Matyas

Submitted by admin on Tue, 01/26/2010 - 10:55am

Associate Dean, Graduate Education
Professor (Microscopic Anatomy)
Comparative Biology and Experimental Medicine (CBEM)

Degrees and Board Certification: 

MSc, PhD

Contact Information: 

+1 (403) 220-7189
TRW 2D13
HM 440


Dr. Matyas comes to UCVM from the Faculty of Medicine at the University of Calgary. He graduated from Cornell University in 1978 with an A.B. in biology. Dr. Matyas went on to study for his M.Sc. at Cornell before coming to the U of C for his Ph.D. under Dr. Cy Frank. He will be a Professor in the Faculty of Veterinary Medicine and is a member of the Canadian Arthritis Network and is an Investigator, The Arthritis Society. Current Research Programmes include: Comparative animal models of joint injury and repair. (CIHR) Contribution of stem cells to skeletal healing. (NIH) Functional imaging of connective tissues (cartilage, bone, intervertebral disc) (CFI) Stereology of connective tissues (NSERC)

Eugene Janzen

Submitted by admin on Tue, 01/26/2010 - 9:50am

Professor, Department of Production Animal Health
Assistant Dean Clinical Practice

Contact Information: 

+1 (403) 210-3972
TRW 2D11



Dr. Janzen received his Doctor of Veterinary Medicine (D.V.M.) in 1972 from the Western College of Veterinary Medicine, Saskatoon, Saskatchewan. Dr. Janzen spent three years practicing in northeastern Alberta before returning to the Western College of Veterinary Medicine on an Alberta-sponsored fellowship to complete a post-graduate degree. Dr. Janzen received an M.V.S. degree from the University of Melbourne, Australia in 1977. In 1977, he accepted a position with the Ambulatory Clinic at the Western College of Veterinary Medicine, Saskatoon, Saskatchewan. In this position, Dr. Janzen has spent his time working with a general interest in beef cattle medicine. Dr. Janzen became associated with Feedlot Health Management Services in 2003.

John Gilleard

Submitted by admin on Mon, 01/25/2010 - 3:49pm

Associate Dean, Research
Professor (Parasitology)
Comparative Biology and Experimental Medicine (CBEM)

Degrees and Board Certification: 


Contact Information: 

+1 (403) 210-6327
TRW 2D10
HS 2557


Dr Gilleard obtained his BVSc from the Faculty of Veterinary Medicine, University of Liverpool in 1987. After three years in general veterinary practice in the UK, he undertook a PhD in Parasitology at the University of Glasgow. He then spent 5 years as a post-doctoral researcher in the Wellcome Centre for Molecular Parasitology, at the Department of Genetics in the University of Glasgow. In 1998 Dr Gilleard was awarded a Wellcome Trust Travel Fellowship during which he spent 2 years in the Faculty of Medicine, University of Calgary. He then returned to a faculty position at the Faculty of Veterinary Medicine, University of Glasgow, in 2000 and was appointed Professor of Veterinary and Molecular Parasitology at Glasgow in 2007.

Research personnel and trainees : 

Currently accepting applications for graduate students (go to