Li-Fang (Jack) Chu

Assistant Professor

Comparative Biology and Experimental Medicine

Full Member

Reproduction and Regenerative Medicine Research Group

PhD

Baylor College of Medicine

BSc

National Taiwan University

Contact information

Phone

Office: 403-210-7233

Web presence

Chu Laboratory

Location

Office : HMRB408

Preferred method of communication

Please contact the faculty member directly at the email or phone number listed above.  If you are not able to reach them, the faculty assistant listed below may be able to help.

Faculty/Admin Assistant

Name:Stephanie Hawes

Phone:+1 (403) 210-7024

Email:shawes@ucalgary.ca


Research and teaching

Research Interests

  • Stem Cells and Regenerative Medicine
  • Cellular Reprogramming
  • Developmental Clock
  • Gene Oscillation
  • Gene Editing

Research / Scholarly Activities

The interest of the Chu laboratory is to identify the principles governing temporal and spatial patterning in development and disease. Following fertilization, the early mammalian embryonic development process constitutes a rapid series of well-coordinated cellular events that are essential to set the organism’s body plan. During this process, the temporal and spatial coordination between multiple cell types and tissues is particularly important because the variation in the relative timing of these processes can have serious consequences for the health and well-being of an organism. The genetic and molecular basis of developmental timing is largely unknown and remains an enigma. To begin addressing these questions, they recently developed an in vitro segmentation clock model derived from human embryonic stem cells. Equipped with this novel system, they hope to understand how this developmental clock operates and how mis-regulation of the clock causes congenital vertebral malformation and identify novel therapeutic targets. They are also interested in better understanding early embryogenesis, cellular reprogramming and disease modeling. The lab employs a combination of approaches including genetically engineered pluripotent stem cells, reprogramming, molecular biology, bulk and single-cell transcriptomics & bioinformatics, organoids, real-time live-cell imaging, and animal models.


Biography

Dr. Chu received his PhD in cell and molecular biology from Baylor College of Medicine. His doctoral training focused on investigating the relationship between early embryogenesis and pluripotent states in vitro. As a postdoctoral fellow and scientist in Dr. James Thomson’s lab at the Morgridge Institute for Research (affiliated with the University of Wisconsin-Madison) where he became interested in studying developmental timing. Dr. Chu joined the Department of Comparative Biology & Experimental Medicine in August 2020 as an Assistant Professor, Faculty of Veterinary Medicine (Foothills campus). His is also affiliated with the Alberta Children’s Hospital Research Institute (ACHRI). His research interests focus on using pluripotent stem cells modeling development and disease, and to identify novel therapeutic strategies for regenerative medicine. 


Publications