Sabine Gilch

Associate Professor

Comparative Biology and Experimental Medicine

Tier II Canada Research Chair in Prion Disease Research

Research Chair

Associate Member

Wildlife Health & Ecology Research Group

Full Member

Infection Biology Research Group

PhD (Molecular Biotechnology)

Technical University of Munich, Germany, 2009

Contact information

Phone

Web presence

Gilch Lab

Location

Office : HRIC1AC66

Preferred method of communication

Please contact the faculty member directly at the email or phone number listed above.  If you are not able to reach them, the faculty assistant listed below may be able to help.

Faculty/Admin Assistant

Name:Mary Anderson

Phone:+1 (403) 210-6150

Email:andersmk@ucalgary.ca

 


Research and teaching

Research Interests

  • Infection Biology

Research / Scholarly Activities

We use cell culture and animal models to study the molecular and cellular biology of prion infections. Prions are unique pathogens that consist solely of a misfolded isoform of the cellular prion protein PrPc, denominated PrPSc. Prominent examples for prion diseases are Creutzfeldt-Jacob disease (CJD) in humans, bovine spongiform encephalopathy (BSE) in cows and chronic wasting disease (CWD) in cervids. Our research program addresses the question how prion infection interferes with neuronal metabolism, and how this may lead to neurodegeneration. Furthermore, we use peptide aptamers for interference with prion propagation and for characterization of the PrPc-PrPSc binding interface. Another focus of research is CWD and aims to understand the molecular basis of the unusual peripheral distribution and shedding of CWD prions, e.g. in saliva, urine or feces. The long-term goal of our research is to translate basic research into novel diagnostic or therapeutic targets to combat prion diseases.


Biography

Dr. Gilch obtained her PhD in Molecular Biotechnology in 2009 from the Technical University of Munich, Germany. She undertook postdoctoral studies on the molecular and cellular biology of prion infection at the Technical University of Munich and the University of Wyoming in Laramie, USA. In 2013, Dr. Gilch joined the UCVM Faculty as Assistant Professor and TierII Canada Research Chair.