Research

Dendritic cells and Macrophages serve as a vital link between the innate and adaptive immune systems through their ability to phagocytose and present antigen. They are also vital in the clearance of pathogens and homeostatic debris by their fine-tuned ability to engulf and digest cell-associated material. We explore the cellular mechanisms which make these processes possible through high-resolution microscopy and other cutting-edge techniques.

Antigen-presenting dendritic cells serve as an important line of defense against the development of cancer by activating specific cancer-killing T cells. However, tumours have evolved complex strategies to evade recognition from phagocytes. We utilize our expertise in innate immune cell biology to better understand how to enhance our immune system's ability to kill cancer cells.