Publications

  • Lara, N. L. M., Jeyhoonabadi, M. A., Dardari, R., Elsenhans, A., Su, L., Sakib, S., & Dobrinski, I. (2025). Platelet-derived growth factor signaling in porcine testicular tubular somatic cells. Cell and Tissue Research, 402(1), 79–96. https://doi.org/10.1007/s00441-025-04004-x
  • Lara, N. L. M., Elsenhans, A., Dardari, R., & Dobrinski, I. (2024). The role of primary cilia in the testis. Current Opinion in Endocrinology, Metabolism & Research, 34, 100508. https://doi.org/10.1016/j.coemr.2024.100508. 
  • Lara, N. L. M., Goldsmith, T., Rodriguez-Villamil, P., Ongaratto, F., Solin, S., Webster, D., Ganbaatar, U., Hodgson, S., Corbiere, S. M. A. S., Bondareva, A., Carlson, D. F., & Dobrinski, I. (2023). DAZL knockout pigs as recipients for spermatogonial stem cell transplantation. Cells, 12(21), 21. https://doi.org/10.3390/cells12212582. 
  • Voigt, A. L., Lara, N. L. M., & Dobrinski, I. (2023). Comparing the adult and pre-pubertal testis: Metabolic transitions and the change in the spermatogonial stem cell metabolic microenvironment. Andrology, 23, 1–15. https://doi.org/10.1111/andr.13397. 
  • Voigt, A. L., Dardari, R., Lara, N. L. M., He, T., Steele, H., Dufour, A., Orwig, K. E., & Dobrinski, I. (2023). Multiomics approach to profiling Sertoli cell maturation during development of the spermatogonial stem cell niche. Molecular Human Reproduction, 29(3), gaad004. https://doi.org/10.1093/molehr/gaad004. 
  • Sakib, S., Lara, N. L. M., Huynh, B. C., & Dobrinski, I. (2022). Organotypic rat testicular organoids for the study of testicular maturation toxicology. Frontiers in Endocrinology, 13, 892342. https://doi.org/10.3389/fendo.2022.892342. 
  • Voigt, A. L., Dardari, R., Su, L., Lara, N. L. M., Sinha, S., Jaffer, A., Munyoki, S. K., Alpaugh, W. A., Dufour, A., Biernaskie, J., Orwig, K. E., & Dobrinski, I. (2022). Metabolic transitions define spermatogonial stem cell maturation. Human Reproduction, 37(9), 2095–2112. https://doi.org/10.1093/humrep/deac157. 
  • Thiageswaran, S., Steele, H., Voigt, A. L., & Dobrinski, I. (2022). A role for exchange of extracellular vesicles in porcine spermatogonial co-culture. International Journal of Molecular Sciences, 23, 4535. https://doi.org/10.3390/ijms23094535. 
  • Voigt, A. L., Kondro, D. A., Powell, D., Valli-Pulsaki, H., Ungrin, M., Stukenborg, J.-B., Klein, C., Lewis, I. A., Orwig, K. E., & Dobrinski, I. (2021). Unique metabolic phenotype and metabolic maturation in juvenile male germ cells. The FASEB Journal, 35(5), e2151. https://doi.org/10.1096/fj.202002799r. 
  • Webster, D., Bondareva, A., Solin, S., Goldsmith, T., Su, L., Lara, N. L. M., Carlson, D. F., & Dobrinski, I. (2021). Targeted gene editing in porcine spermatogonia. Frontiers in Genetics, 11, 627673. https://doi.org/10.3389/fgene.2020.627673. 
  • Alpaugh, W., Voigt, A. L., Dardari, R., Su, L., Al-Khatib, I., Shin, W., Goldsmith, T. M., Coyle, K. M., Tang, L. A., Shutt, T. E., Klein, C., Biernaskie, J., & Dobrinski, I. (2021). Loss of ubiquitin carboxy-terminal hydrolase L1 impairs long-term differentiation competence and metabolic regulation in murine spermatogonial stem cells. Cells, 10, 2265. https://doi.org/10.3390/cells10092265. 
  • Sakib, S., Voigt, A., Lara, N. L. M., Su, L., Ungrin, M., Rancourt, D., & Dobrinski, I. (2021). The proliferation of pre-pubertal porcine spermatogonia in stirred suspension bioreactors is partially mediated by the Wnt/β-catenin pathway. International Journal of Molecular Sciences, 22, 13549. https://doi.org/10.3390/ijms222413549. 
  • Goldsmith, T. M., Sakib, S., Webster, D., Carlson, D. F., Van Der Hoorn, F., & Dobrinski, I. (2020). A reduction of primary cilia but not hedgehog signaling disrupts morphogenesis in testicular organoids. Cell & Tissue Research, 380(1), 191–200. https://doi.org/10.1007/s00441-019-03121-8
  • Nicholls, P. K., Schorle, H., Nagvi, S., Hu, Y.-C., Yuting, F., Carmell, M. A., Dobrinski, I., Watson, A. L., Carlson, D. F., Fahrenkrug, S. C., & Page, D. C. (2019). Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proceedings of the National Academy of Sciences USA, 116(51), 25677–25687. https://doi.org/10.1073/pnas.1910733116
  • Burrell, K., Dardari, R., Goldsmith, T., Toms, D., Villagomez, D. A. F., King, W. A., Ungrin, M., West, F. D., & Dobrinski, I. (2019). Stirred suspension bioreactor culture of porcine induced pluripotent stem cells. Stem Cells and Development, 28(18), 1264–1275. https://doi.org/10.1089/scd.2019.0111
  • Sakib, S., Uchida, A., Valenzuela-Leon, P., Yu, Y., Valli-Pulaski, H., Orwig, K., Ungrin, M., & Dobrinski, I. (2019). Formation of organotypic testicular organoids in microwell culture. Biology of Reproduction, 100(6), 1648–1660. https://doi.org/10.1093/biolre/ioz053
  • Fayomi, A. P., Peters, K., Sukhwani, M., Valli-Pulaski, H., Shetty, G., Meistrich, M. L., Houser, L., Robertson, N., Roberts, V., Ramsey, C., Hanna, C., Hennebold, J. D., Dobrinski, I., & Orwig, K. E. (2019). Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science, 363(6433), 1314–1319. https://doi.org/10.1126/science.aav2914. 
  • Tang, L., Bondareva, A., Gonzalez, R., Rodriguez-Sosa, J. R., Carlson, D. F., Webster, D., Fahrenkrug, S., & Dobrinski, I. (2018). TALEN-mediated gene targeting in porcine spermatogonia. Molecular Reproduction and Development, 85, 250–261. https://doi.org/10.1002/mrd.22961
  • Dores, C., Alpaugh, W., Su, L., Biernaskie, J., & Dobrinski, I. (2017). Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro. Cell & Tissue Research, 368, 215–223. https://doi.org/10.1007/s00441-016-2523-6. 
  • Rodriguez-Sosa, J. E., Bondareva, A., Tang, L., Avelar, G. F., Coyle, K. M., Modelski, M., Alpaugh, W., Conley, A., Wynne-Edwards, K., Franca, L. R., Meyers, S., & Dobrinski, I. (2014). Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice. Molecular and Cellular Endocrinology, 398, 89–100. https://doi.org/10.1016/j.mce.2014.10.004
  • Ou, Y., Dores, C., Rodriguez-Sosa, J. R., Van Der Hoorn, F., & Dobrinski, I. (2014). Primary cilia in the developing pig testis. Cell & Tissue Research, 358(2), 597–605. https://doi.org/10.1007/s00441-014-1973-y.
  • Arregui, L., Dobrinski, I., & Roldan, E. R. (2014). Germ cell survival and differentiation after xenotransplantation of testis tissue from three endangered species: Iberian lynx (Lynx pardinus), Cuvier's gazelle (Gazella cuvieri) and Mohor gazelle (G. dama mhorr). Reproduction, fertility, and development, 26(6), 817–826. https://doi.org/10.1071/RD12411. 
  • He, Z., Jiang, J., Kokkinaki, M., Tang, L., Zeng, W., Gallicano, I., Dobrinski, I., & Dym, M. (2013). MiRNA-20 and MiRNA-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnad1. Stem Cells, 31, 2205–2217. https://doi.org/10.1002/stem.1474
  • Zeng, W., Tang, L., Bondareva, A., Honaramooz, A., Tanco, V., Dores, C., Megee, S., Modelski, M., Rodriguez-Sosa, J. R., Paczkowski, M., Silva, E., Wheeler, M., Krisher, R. L., & Dobrinski, I. (2013). Viral transduction of male germline stem cells results in transgene transmission after germ cell transplantation in pigs. Biology of Reproduction, 88(1), 27. https://doi.org/10.1095/biolreprod.112.104422
  • Zeng, W., Tang, L., Bondareva, A., Luo, J., Megee, S. O., Modelski, M., Blash, S., Melican, D. T., Destrempes, M., Overton, S. A., Gavin, W. C., Ayres, S., Echelard, Y., & Dobrinski, I. (2012). Non-viral transfection of goat germline stem cells by nucleofection results in production of transgenic sperm after germ cell transplantation. Molecular Reproduction and Development, 79, 255–261. https://doi.org/10.1002/mrd.22014. 
  • He, Z., Kokkinaki, M., Jiang, J., Dobrinski, I., & Dym, M. (2010). Isolation, characterization, and culture of human spermatogonia. Biology of Reproduction, 82, 363–372. https://doi.org/10.1095/biolreprod.109.078550. 
  • Luo, J., Megee, S., & Dobrinski, I. (2009). Asymmetric distribution of UCH-L1 in spermatogonia is associated with maintenance and differentiation of spermatogonial stem cells. Journal of Cellular Physiology, 220, 460–468. https://doi.org/10.1002/jcp.21789. 
  • Rathi, R., Zeng, W., Megee, S., Conley, A., Meyers, S., & Dobrinski, I. (2008). Maturation of testicular tissue from infant monkeys after xenografting into mice. Endocrinology, 149(10), 5288–5296. https://doi.org/10.1210/en.2008-0311. 
  • Honaramooz, A., Megee, S., Zeng, W., Destrempes, M. M., Overton, S. A., Luo, J., Galantino-Homer, H., Modelski, M., Chen, F., Blash, S., Melican, D. T., Gavin, W. G., Ayres, S., Yang, F., Wang, P. J., Echelard, Y., & Dobrinski, I. (2008a). Adeno-associated virus (AAV)-mediated transduction of male germline stem cells results in transgene transmission after germ cell transplantation. The FASEB Journal, 22, 374–382. https://doi.org/10.1096/fj.07-8935com. 
  • Honaramooz, A., Megee, S., Rathi, R., & Dobrinski, I. (2007). Building a testis: Formation of functional testis tissue after transplantation of isolated porcine (Sus scrofa) testis cells. Biology of Reproduction, 76, 43–47. https://doi.org/10.1095/biolreprod.106.054999. 
  • Luo, J., Megee, S., Rathi, R., & Dobrinski, I. (2006). Protein gene product 9.5 is a spermatogonia-specific marker in pig testis: Application to enrichment and culture of porcine spermatogonia. Molecular Reproduction and Development, 73, 1531–1540. https://doi.org/10.1002/mrd.20529. 
  • Honaramooz, A., Li, M.-W., Penedo, C. T., Meyers, S. A., & Dobrinski, I. (2004). Accelerated maturation of primate testis by xenografting into mice. Biology of Reproduction, 70, 1500–1503. https://doi.org/10.1095/biolreprod.103.025536. 
  • Honaramooz, A., Behboodi, E., Megee, S. O., Overton, S. A., Galantino-Homer, H., Echelard, Y., & Dobrinski, I. (2003). Fertility and germline transmission of donor haplotype following germ cell transplantation in immunocompetent goats. Biology of Reproduction, 69, 1260–1264. https://doi.org/10.1095/biolreprod.103.018788. 
  • Honaramooz, A., Snedaker, A., Boiani, M., Schöler, H. R., Dobrinski, I., & Schlatt, S. (2002). Sperm from neonatal mammalian testes grafted in mice. Nature, 418, 778–781. https://doi.org/10.1038/nature00918. 
  • Honaramooz, A., Megee, S. O., & Dobrinski, I. (2002). Germ cell transplantation in pigs. Biology of Reproduction, 66, 21–28. https://doi.org/10.1095/biolreprod66.1.21. 
Full List - PubMed