Research

The goal of this project is to translate a novel stem cell based therapy and develop criteria toward a future clinical trial to improve functional recovery and help survivors of burn injury return to work and improve their social interactions.

Aim 1

In the first aim of this project, we will ask whether transplanting human skin stem cells into a model of split thickness skin graft can regenerate new skin tissue within the graft and restore its normal, healthy function.

Learn more

Aim 2

In this aim, we use biomedical engineering strategies to enhance dermal stem cell growth in order to produce sufficient numbers of stem cells for use in human patients. In addition, we hope to develop a 3D, biodegradable scaffold that supports stem cell survival within a graft.

Learn more

Aim 3

Third, we aim to determine the mechanical properties of the split thickness skin graft combined with dermal stem cells. In addition, we are also focused on evaluating non-invasive tools to measure wound healing progress and the properties of scars.

Learn more

Aim 4

Finally, we will assess the expectations and experiences of burn survivors, persons at risk of burn injury (ie. firefighters) and plastic surgeons (all end users of split thickness skin grafts) in order to gain a better understanding of which aspects of skin graft "outcome" are most critical to improving their quality of life.

Learn more