Publications

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  1. Stietz, M.S., Liang, X., Li, H.,Zhang, X., Dong TG . (2020) TssA–TssM–TagA interaction modulates type VI secretion system sheath-tube assembly in Vibrio cholerae. Nature Communications 11, 5065 . https://doi.org/10.1038/s41467-020-18807-9
  2. Kamal, F., Liang, X., Manera, K., Pei, T.T., Kim, H., Lam, L.G., Pun, A., Hersch, S.J., Dong TG (2020) Differential cellular response to translocated toxic effectors and physical penetration by the type VI secretion system. Cell Reports.31, 107766 
  3. Pei, TT#; Li, H#; Liang, X#; Wang, Z; Liu, G; Wu, L; Kim, H; Xie, Z; Yu, M; Lin, S; Xu, P; Dong, TG.*(2020) Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system, Nature Communications, DOI:10.1038/s41467-020-15774-z

  4. Hersch, S. J., Watanabe, N., Stietz, M. S., Manera, K., Kamal, F., Burkinshaw, B., … Dong, T. G. (2020). Envelope stress responses defend against type six secretion system attacks independently of immunity proteins. Nature Microbiology. https://doi.org/10.1038/s41564-020-0672-6

  5. Stietz M, Liang X, Wong M, Hersch S, Dong T (2019). The double tubular contractile structure of the type VI secretion system displays striking flexibility and elasticity. Journal of Bacteriology, pii: JB.00425-19. doi: 10.1128/JB.00425-19
  6. Finn T, Scriver L, Lam L, Duong M, Peirano G, Lynch T,  Dong T, Pitout J, DeVinney R (2019). A comprehensive account of Escherichia coli Sequence Type 131 in wastewater reveals an abundance of fluoroquinolone resistant clade A strains. Applied and Environmental Microbiology, Accepted  
  7. Liang X, Kamal F, Pei T.T., Xu P., Mekalanos J.J., Dong T (2019). An on-board checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae.  Proc. Natl. Acad. Sci. USA., 116(46):23292-23298. doi: 10.1073/pnas.1914202116. Epub 2019 Oct 28
  8. Burkinshaw B, Liang X, Wong M, Le A, Lam L, Dong T (2018). A Type VI Secretion System effector delivery mechanism dependent on PAAR and a chaperone/co-chaperone complex , Nature Microbiology 3(5):632–640 
  9. Ho B, Fu Y, Dong TG, Mekalanos JJ.  (2017) Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc. Natl. Acad. Sci. U. S. A.  i 114(35):9427-9432
  10. Si M, Wang Y, Zhang B, Zhao C, Kang Y, Bai H, Wei D, Zhu L, Zhang L, Dong TG, Shen X. (2017) The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition . Cell Reports. 2017 Jul 25;20(4):949-959.
  11. Si M, Zhao C, Brianne Burkinshaw#, Zhang B, Wei D, Wang Y, Dong T.G*, Shen X* (2017) Manganese scavenging and oxidative stress response mediated by the type VI secretion system in Burkholderia thailandensis. Proc. Natl. Acad. Sci. U. S. A. (in press) *Co-correspondence author,  #trainee in Dong lab.       
  12. Wong M, Liang X, Smart M, Tang L, Moore R, Ingalls B, Dong T.G, (2016) Microbial herd protection mediated by antagonistic interaction in polymicrobial communities .  Applied and Environmental Microbiology, spotlight article                                                                                                            
  13. Wilton M*., Wong M.*, Tang L., Liang X., Moore R., Parkins M., Lewenza S., Dong T.G. (2016). Chelation of membrane-bound cations by extracellular DNA activates the T6SS in Pseudomonas aeruginosa.  Infection and Immunity,  84(8):2355-61 . * Contributed equally          
  14. Tang L., Liang X., Moore, R., and Dong, T. G. (2015). Commentary: The icmF3 Locus is Involved in Multiple Adaptation- and Virulence-related Characteristics in Pseudomonas aeruginosa PAO1 . Front. Cell. Infect. Microbiol., 83. doi:10.3389/fcimb.2015.00083.
  15. Liang X., Moore R., Wilton M., Wong M., Lam L. and Dong T. (2015) Identification of divergent type VI secretion effectors . Proc. Natl. Acad. Sci. U. S. A.  112:9106-11                                                   
  16. Dong T*,  Dong S#,  Catalano C#, Moore R#, Liang X#, Mekalanos J (2015)  Generation of reactive oxygen species by lethal attacks from competing microbes.  Proc Natl Acad Sci  U S A  112(7):2181-6  *Co-correspondence author,  #trainees in Dong lab.                                               
  17. Altindis E*, Dong T*, Catalano C#, Mekalanos J (2015)  Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair . mBio. 10;6(2):e00075   * Contributed equally                                                                                                                                   
  18. Ho BT, Dong T, Mekalanos JJ (2014) A view to a kill: the bacterial type 6 secretion system.  Cell Host & Microbe,  15(1):9-21         
  19. Dong T, Ho BT, Yoder-Himes DR, and Mekalanos JJ (2013) Identification of T6SS-dependent effector and immunity proteins by Tn-seq in  Vibrio cholerae.  Proc Natl Acad Sci U S A  110:2623-2628