Publications

Inhibitory medial zona incerta pathway drives exploratory behavior by inhibiting glutamatergic cuneiform neurons.

Sharma S, Badenhorst CA, Ashby DM, Di Vito SA, Tran MA, Ghavasieh Z, Grewal GK, Belway CR, McGirr A, Whelan PJ.

Nat Commun. 2024 Feb 7;15(1):1160. doi: 10.1038/s41467-024-45288-x.PMID: 38326327

 

High-throughput Gait Acquisition System for Freely Moving Mice.

Molina LA, Milla-Cruz JJ, Ghavasieh Z, Kim LH, Cheng N, Whelan PJ.

J Neurophysiol. 2023 Nov 1;130(5):1081-1091. doi: 10.1152/jn.00133.2023. Epub 2023 Sep 20.PMID: 37728487

 

The Mesencephalic Locomotor Region: Beyond Locomotor Control.

Noga BR, Whelan PJ.

Front Neural Circuits. 2022 May 9;16:884785. doi: 10.3389/fncir.2022.884785. eCollection 2022.

PMID: 35615623

 

Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26.

Bernhardt N, Sayyab S, Memic F, Velica A, Tran MA, Vieillard J, Chersa T, Andersson L,  Whelan PJ, Boije H, Kullander K.

eNeuro. 2022 Mar 14;9(2):ENEURO.0518-21.2022. doi: 10.1523/ENEURO.0518-21.2022. Print 2022 Mar-Apr.

PMID: 35210288

 

Contributions of h- and Na+/K+ Pump Currents to the Generation of Episodic and Continuous Rhythmic Activities.

Sharples SA, Parker J, Vargas A, Milla-Cruz JJ, Lognon AP, Cheng N, Young L, Shonak A, Cymbalyuk GS, Whelan PJ.

Front Cell Neurosci. 2022 Feb 4;15:715427. doi: 10.3389/fncel.2021.715427. eCollection 2021.

PMID: 35185470

 

Fiber Photometry for Monitoring Cerebral Oxygen Saturation in Freely-moving Rodents.

Yu L, Thurston EMS, Hashem M, Dunn JF, Whelan PJ, Murari K.

Biomed Opt Express. 2020 Jun 4;11(7):3491-3506. doi: 10.1364/BOE.393295. eCollection 2020 Jul 1.

PMID: 33014546

 

A dynamic role for dopamine receptors in the control of mammalian spinal networks.

Sharples SA, Burma NE, Borowska-Fielding J, Kwok CHT, Eaton SEA, Baker GB, Jean-Xavier C, Zhang Y, Trang T, Whelan PJ.

Sci Rep. 2020 Oct 2;10(1):16429. doi: 10.1038/s41598-020-73230-w.

PMID: 33009442

 

The Effects of a Ketogenic Diet on Sensorimotor Function in a Thoracolumbar Mouse Spinal Cord Injury Model.

Mayr KA, Kwok CHT, Eaton SEA, Baker GB, Whelan PJ.

eNeuro. 2020 Aug 13;7(4):ENEURO.0178-20.2020. doi: 10.1523/ENEURO.0178-20.2020. Print 2020 Jul/Aug.

PMID: 32680835

 

Visual Gait Lab: A User-friendly Approach to Gait Analysis.

Fiker R, Kim LH, Molina LA, Chomiak T, Whelan PJ.

J Neurosci Methods. 2020 Jul 15;341:108775. doi: 10.1016/j.jneumeth.2020.108775. Epub 2020 May 16.

PMID: 32428621

 

An Economical Solution to Record and Control Wheel-running for Group-housed Mice.

Mayr KA, Young L, Molina LA, Tran MA, Whelan PJ.

J Neurosci Methods. 2020 Feb 1;331:108482. doi: 10.1016/j.jneumeth.2019.108482. Epub 2019 Nov 13.

PMID: 31733283

A Supervised Machine Learning Approach to Characterize Spinal Network Function.

Dalrymple AN, Sharples SA, Osachoff N, Lognon AP, Whelan PJ.

J Neurophysiol. 2019 Jun 1;121(6):2001-2012. doi: 10.1152/jn.00763.2018. Epub 2019 Apr 3.

PMID: 30943091

 

Towards a Connectome of Descending Commands Controlling Locomotion.

Sharma S, Kim LH, Whelan PJ.

Curr Opin Physiol. 2019 Apr;8:70-75. doi: 10.1016/j.cophys.2018.12.005. Epub 2019 Jan 2.

ISSN: 2468-8673. Review.

 

Orexinergic Modulation of Spinal Motor Activity in the Neonatal Mouse Spinal Cord.

Biswabharati S, Jean-Xavier C, Eaton SEA, Lognon AP, Brett R, Hardjasa L, Whelan PJ.

eNeuro. 2018 Nov 8;5(5):ENEURO.0226-18.2018. doi: 10.1523/ENEURO.0226-18.2018. eCollection 2018 Sep-Oct.

PMID: 30417080

 

Optogenetic Activation of A11 Region Increases Motor Activity.

Koblinger K, Jean-Xavier C, Sharma S, Füzesi T, Young L, Eaton SEA, Kwok CHT, Bains JS, Whelan PJ.

Front Neural Circuits. 2018 Oct 11;12:86. doi: 10.3389/fncir.2018.00086. eCollection 2018.

PMID: 30364230

 

Parallel Descending Dopaminergic Connectivity of A13 Cells to the Brainstem Locomotor Centers.

Sharma S, Kim LH, Mayr KA, Elliott DA, Whelan PJ.

Sci Rep. 2018 May 22;8(1):7972. doi: 10.1038/s41598-018-25908-5.

PMID: 29789702

 

Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function.

Shah PT, Stratton JA, Stykel MG, Abbasi S, Sharma S, Mayr KA, Koblinger K, Whelan PJ, Biernaskie J.

Cell. 2018 May 3;173(4):1045-1057.e9. doi: 10.1016/j.cell.2018.03.063.

PMID: 29727663

 

Marking the Differences in Motoneurons.

Sharples SA, Whelan PJ.

Elife. 2018 Apr 27;7:e36832. doi: 10.7554/eLife.36832.

PMID: 29701592

 

Retracing Your Footsteps: Developmental Insights to Spinal Network Plasticity Following Injury.

Jean-Xavier C, Sharples SA, Mayr KA, Lognon AP, Whelan PJ.

J Neurophysiol. 2018 Feb 1;119(2):521-536. doi: 10.1152/jn.00575.2017. Epub 2017 Oct 25.

PMID: 29070632. Review.

 

Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.

Kim LH, Sharma S, Sharples SA, Mayr KA, Kwok CHT, Whelan PJ.

Front Neurosci. 2017 Oct 18;11:581. doi: 10.3389/fnins.2017.00581. eCollection 2017.

PMID: 29093660. Review.

 

Decerebrate Mouse Model for Studies of the Spinal Cord Circuits.

Meehan CF, Mayr KA, Manuel M, Nakanishi ST, Whelan PJ.

Nat Protoc. 2017 Apr;12(4):732-747. doi: 10.1038/nprot.2017.001. Epub 2017 Mar 9.

PMID: 28277546

 

AlphaB-crystallin Regulates Remyelination After Peripheral Nerve Injury.

Lim EF, Nakanishi ST, Hoghooghi V, Eaton SE, Palmer AL, Frederick A, Stratton JA, Stykel MG, Whelan PJ, Zochodne DW, Biernaskie J, Ousman SS.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1707-E1716. doi: 10.1073/pnas.1612136114. Epub 2017 Jan 30.

PMID: 28137843 

 

Modulation of Rhythmic Activity in Mammalian Spinal Networks Is Dependent on Excitability State.

Sharples SA, Whelan PJ.

eNeuro. 2017 Jan 27;4(1):ENEURO.0368-16.2017. doi: 10.1523/ENEURO.0368-16.2017. eCollection 2017 Jan-Feb.

PMID: 28144626

 

Modulatory and Plastic Effects of Kinins on Spinal Cord Networks.

Mandadi S, Leduc-Pessah H, Hong P, Ejdrygiewicz J, Sharples SA, Trang T, Whelan PJ.

J Physiol. 2016 Feb 15;594(4):1017-36. doi: 10.1113/JP271152.

PMID: 26634895

 

Dopaminergic Modulation of Locomotor Network Activity in the Neonatal Mouse Spinal Cord.

Sharples SA, Humphreys JM, Jensen AM, Dhoopar S, Delaloye N, Clemens S, Whelan PJ.

J Neurophysiol. 2015 Apr 1;113(7):2500-10. doi: 10.1152/jn.00849.2014. Epub 2015 Feb 4.

PMID: 25652925

 

Characterization of A11 Neurons Projecting to the Spinal Cord of Mice.

Koblinger K, Füzesi T, Ejdrygiewicz J, Krajacic A, Bains JS, Whelan PJ.

PLoS One. 2014 Oct 24;9(10):e109636. doi: 10.1371/journal.pone.0109636. eCollection 2014.

PMID: 25343491

 

Dopamine: A Parallel Pathway for the Modulation of Spinal Locomotor Networks.

Sharples SA, Koblinger K, Humphreys JM, Whelan PJ.

Front Neural Circuits. 2014 Jun 16;8:55. doi: 10.3389/fncir.2014.00055. eCollection 2014.

PMID: 24982614. Review.

 

Identification of Multisegmental Nociceptive Afferents that Modulate Locomotor Circuits in the Neonatal Mouse Spinal Cord.

Mandadi S, Hong P, Tran MA, Bráz JM, Colarusso P, Basbaum AI, Whelan PJ.

J Comp Neurol. 2013 Aug 15;521(12):2870-87. doi: 10.1002/cne.23321.

PMID: 23436436

 

Noradrenaline is a Stress-associated Metaplastic Signal at GABA Synapses.

Inoue W, Baimoukhametova DV, Füzesi T, Wamsteeker Cusulin JI, Koblinger K, Whelan PJ, Pittman QJ, Bains JS.

Nat Neurosci. 2013 May;16(5):605-12. doi: 10.1038/nn.3373. Epub 2013 Apr 7.

PMID: 23563580

 

Serotonin 1A Receptors Alter Expression of Movement Representations.

Scullion K, Boychuk JA, Yamakawa GR, Rodych JT, Nakanishi ST, Seto A, Smith VM, McCarthy RW, Whelan PJ, Antle MC, Pittman QJ, Teskey GC.

J Neurosci. 2013 Mar 13;33(11):4988-99. doi: 10.1523/JNEUROSCI.4241-12.2013.

PMID: 23486969

 

Control of neonatal spinal networks by nociceptors: a potential role for TRP channel based therapies.

Mandadi S, Hong P, Dhoopar AS, Whelan P.

J Pharm Pharm Sci. 2013;16(2):313-20. doi: 10.18433/j3w02s.

PMID: 23958200. Review. 

 

Dopamine exerts activation-dependent modulation of spinal locomotor circuits in the neonatal mouse.

Humphreys JM, Whelan PJ.

J Neurophysiol. 2012 Dec;108(12):3370-81. doi: 10.1152/jn.00482.2012. Epub 2012 Sep 19.

PMID: 22993259

 

Rodent isolated spinal cord preparations to examine motor output.

Mandadi S, Nakanishi ST, Han P, Humphreys JM, Whelan PJ.

In: Ballanyi K. (eds) Isolated Central Nervous System Circuits. Neuromethods, vol 73. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-020-5_15

 

A decerebrate adult mouse model for examining the sensorimotor control of locomotion.

Nakanishi ST, Whelan PJ.

J Neurophysiol. 2012 Jan;107(1):500-15. doi: 10.1152/jn.00699.2011. Epub 2011 Oct 12.

PMID: 21994265

 

Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat.

Roy A, Mandadi S, Fiamma MN, Rodikova E, Ferguson EV, Whelan PJ, Wilson RJ.

J Appl Physiol (1985). 2012 Jan;112(1):212-24. doi: 10.1152/japplphysiol.01303.2010. Epub 2011 Sep 8.

PMID: 21903882

 

Shining light into the black box of spinal locomotor networks.

Whelan PJ.

Philos Trans R Soc Lond B Biol Sci. 2010 Aug 12;365(1551):2383-95. doi: 10.1098/rstb.2009.0322.

PMID: 20603359

 

Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells.

Enjin A, Rabe N, Nakanishi ST, Vallstedt A, Gezelius H, Memic F, Lind M, Hjalt T, Tourtellotte WG, Bruder C, Eichele G, Whelan PJ, Kullander K.

J Comp Neurol. 2010 Jun 15;518(12):2284-304. doi: 10.1002/cne.22332.

PMID: 20437528

 

Diversification of intrinsic motoneuron electrical properties during normal development and botulinum toxin-induced muscle paralysis in early postnatal mice.

Nakanishi ST, Whelan PJ.

J Neurophysiol. 2010 May;103(5):2833-45. doi: 10.1152/jn.00022.2010.

PMID: 20457856

 

Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse.

Dunbar MJ, Tran MA, Whelan PJ.

J Physiol. 2010 Jan 1;588(Pt 1):139-56. doi: 10.1113/jphysiol.2009.177378. Epub 2009 Nov 2.

PMID: 19884315

 

Tumor necrosis factor alpha enhances glutamatergic transmission onto spinal motoneurons.

Han P, Whelan PJ.

J Neurotrauma. 2010 Jan;27(1):287-92. doi: 10.1089/neu.2009.1016.

PMID: 19811092

The involvement of the motor cortex in postural control: a delicate balancing act.

Whelan PJ.

J Physiol. 2009 Aug 1;587(Pt 15):3753. doi: 10.1113/jphysiol.2009.176750.

PMID: 19648441

 

A new method to study sensory modulation of locomotor networks by activation of thermosensitive cutaneous afferents using a hindlimb attached spinal cord preparation.

Mandadi S, Whelan PJ.

J Neurosci Methods. 2009 Sep 15;182(2):255-9. doi: 10.1016/j.jneumeth.2009.06.011. Epub 2009 Jun 18.

PMID: 19540266

 

Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.

Mandadi S, Nakanishi ST, Takashima Y, Dhaka A, Patapoutian A, McKemy DD, Whelan PJ.

Neuroscience. 2009 Sep 15;162(4):1377-97. doi: 10.1016/j.neuroscience.2009.05.063. Epub 2009 May 29.

PMID: 19482068

 

The involvement of the motor cortex in postural control: a delicate balancing act.

Whelan PJ.

J Physiol. 2009 Aug 1;587(Pt 15):3753. doi: 10.1113/jphysiol.2009.176750.

PMID: 19648441 

 

Modulation of AMPA currents by D(1)-like but not D(2)-like receptors in spinal motoneurons.

Han P, Whelan PJ.

Neuroscience. 2009 Feb 18;158(4):1699-707. doi: 10.1016/j.neuroscience.2008.11.040. Epub 2008 Dec 7.

PMID: 19110039

 

Interaction between developing spinal locomotor networks in the neonatal mouse.

Gordon IT, Dunbar MJ, Vanneste KJ, Whelan PJ.

J Neurophysiol. 2008 Jul;100(1):117-28. doi: 10.1152/jn.00829.2007. Epub 2008 Apr 24.

PMID: 18436636

 

Brainstem modulation of locomotion in the neonatal mouse spinal cord.

Gordon IT, Whelan PJ.

J Physiol. 2008 May 15;586(10):2487-97. doi: 10.1113/jphysiol.2007.148320. Epub 2008 Mar 27.

PMID: 18372309

 

Dopaminergic modulation of spinal neuronal excitability.

Han P, Nakanishi ST, Tran MA, Whelan PJ.

J Neurosci. 2007 Nov 28;27(48):13192-204. doi: 10.1523/JNEUROSCI.1279-07.2007.

PMID: 18045913

 

Monoaminergic control of cauda-equina-evoked locomotion in the neonatal mouse spinal cord.

Gordon IT, Whelan PJ.

J Neurophysiol. 2006 Dec;96(6):3122-9. doi: 10.1152/jn.00606.2006. Epub 2006 Sep 6.

PMID: 16956991

 

Deciphering the organization and modulation of spinal locomotor central pattern generators.

Gordon IT, Whelan PJ.

J Exp Biol. 2006 Jun;209(Pt 11):2007-14. doi: 10.1242/jeb.02213.

PMID: 16709903. Review.

 

Monoaminergic establishment of rostrocaudal gradients of rhythmicity in the neonatal mouse spinal cord.

Christie KJ, Whelan PJ.

J Neurophysiol. 2005 Aug;94(2):1554-64. doi: 10.1152/jn.00299.2005. Epub 2005 Apr 13.

PMID: 15829596

 

Development of an inhibitory interneuronal circuit in the embryonic spinal cord.

Xu H, Whelan PJ, Wenner P.

J Neurophysiol. 2005 May;93(5):2922-33. doi: 10.1152/jn.01091.2004. Epub 2004 Dec 1.

PMID: 15574794

 

Modulation of locomotor activity by multiple 5-HT and dopaminergic receptor subtypes in the neonatal mouse spinal cord.

Madriaga MA, McPhee LC, Chersa T, Christie KJ, Whelan PJ.

J Neurophysiol. 2004 Sep;92(3):1566-76. doi: 10.1152/jn.01181.2003. Epub 2004 May 26.

PMID: 15163678

 

Developmental aspects of spinal locomotor function: insights from using the in vitro mouse spinal cord preparation.

Whelan PJ.

J Physiol. 2003 Dec 15;553(Pt 3):695-706. doi: 10.1113/jphysiol.2003.046219. Epub 2003 Oct 3.

PMID: 14528025. Review.

 

Peptidergic activation of locomotor pattern generators in the neonatal spinal cord.

Pearson SA, Mouihate A, Pittman QJ, Whelan PJ.

J Neurosci. 2003 Nov 5;23(31):10154-63. doi: 10.1523/JNEUROSCI.23-31-10154.2003.

PMID: 14602832

 

Electromyogram recordings from freely moving animals.

Whelan PJ.

Methods. 2003 Jun;30(2):127-41. doi: 10.1016/s1046-2023(03)00074-4.

PMID: 12725779. Review.

 

Tissue PO2 and the effects of hypoxia on the generation of locomotor-like activity in the in vitro spinal cord of the neonatal mouse.

Wilson RJ, Chersa T, Whelan PJ.

Neuroscience. 2003;117(1):183-96. doi: 10.1016/s0306-4522(02)00831-x.

PMID: 12605904

 

Locomotor-like activity generated by the neonatal mouse spinal cord.

Bonnot A, Whelan PJ, Mentis GZ, O'Donovan MJ.

Brain Res Brain Res Rev. 2002 Oct;40(1-3):141-51. doi: 10.1016/s0165-0173(02)00197-2.

PMID: 12589913. Review.

 

Spatiotemporal pattern of motoneuron activation in the rostral lumbar and the sacral segments during locomotor-like activity in the neonatal mouse spinal cord.

Bonnot A, Whelan PJ, Mentis GZ, O'Donovan MJ.

J Neurosci. 2002 Feb 1;22(3):RC203. doi: 10.1523/JNEUROSCI.22-03-j0001.2002.

PMID: 11826149

 

Adaptive locomotor plasticity in chronic spinal cats after ankle extensors neurectomy.

Bouyer LJ, Whelan PJ, Pearson KG, Rossignol S.

J Neurosci. 2001 May 15;21(10):3531-41. doi: 10.1523/JNEUROSCI.21-10-03531.2001.

PMID: 11331382

Activity patterns and synaptic organization of ventrally located interneurons in the embryonic chick spinal cord.

Ritter A, Wenner P, Ho S, Whelan PJ, O'Donovan MJ.

J Neurosci. 1999 May 1;19(9):3457-71. doi: 10.1523/JNEUROSCI.19-09-03457.1999.

PMID: 10212306

 

Spontaneous network activity transiently depresses synaptic transmission in the embryonic chick spinal cord.

Fedirchuk B, Wenner P, Whelan PJ, Ho S, Tabak J, O'Donovan MJ.

J Neurosci. 1999 Mar 15;19(6):2102-12. doi: 10.1523/JNEUROSCI.19-06-02102.1999.

PMID: 10066263

 

Comparison of the effects of stimulating extensor group I afferents on cycle period during walking in conscious and decerebrate cats.

Whelan PJ, Pearson KG.

Exp Brain Res. 1997 Dec;117(3):444-52. doi: 10.1007/s002210050239.

PMID: 9438712

 

Plasticity in reflex pathways controlling stepping in the cat.

Whelan PJ, Pearson KG.

J Neurophysiol. 1997 Sep;78(3):1643-50. doi: 10.1152/jn.1997.78.3.1643.

PMID: 9310449

 

Control of locomotion in the decerebrate cat.

Whelan PJ.

Prog Neurobiol. 1996 Aug;49(5):481-515. doi: 10.1016/0301-0082(96)00028-7.

PMID: 8895997. Review.

 

Contribution of hind limb flexor muscle afferents to the timing of phase transitions in the cat step cycle.

Hiebert GW, Whelan PJ, Prochazka A, Pearson KG.

J Neurophysiol. 1996 Mar;75(3):1126-37. doi: 10.1152/jn.1996.75.3.1126.

PMID: 8867123

 

Plasticity of the extensor group I pathway controlling the stance to swing transition in the cat.

Whelan PJ, Hiebert GW, Pearson KG.

J Neurophysiol. 1995 Dec;74(6):2782-7. doi: 10.1152/jn.1995.74.6.2782.

PMID: 8747237

 

Suppression of the corrective response to loss of ground support by stimulation of extensor group I afferents.

Hiebert GW, Whelan PJ, Prochazka A, Pearson KG.

J Neurophysiol. 1995 Jan;73(1):416-20. doi: 10.1152/jn.1995.73.1.416.

PMID: 7714585

 

Stimulation of the group I extensor afferents prolongs the stance phase in walking cats.

Whelan PJ, Hiebert GW, Pearson KG.

Exp Brain Res. 1995;103(1):20-30. doi: 10.1007/BF00241961.

PMID: 7615034

 

Neural mechanisms that contribute to cyclical modulation of the soleus H-reflex in walking in humans.

Yang JF, Whelan PJ.

Exp Brain Res. 1993;95(3):547-56. doi: 10.1007/BF00227148.

PMID: 8224081