Publications

Wound healing and fibroblast diversity

 

1.   Sinha S, Arora R, Kutluberk E, Verly M, Small C, Herik A, Burnett L, Cao L, Manoharan VT, Chockalingam K, van der Vyver M, Ponjevic D, Sparks HD, Morrissy S, Harrop AR, Brenn T, Nikolic A, Temple-Oberle C, Rosin N, Gabriel V, Biernaskie J. Spatial and Single-Cell Transcriptomics Reveal that Oncofetal Reprogramming of Fibroblasts Is Associated with Malignant Degeneration of Burn Scar. Journal of Investigative Dermatology. 2024 Aug 9:S0022-202X(24)01988-2. 

Profiled in: Eureka Alert, UCalgary

 

2.   Sinha S*, Sparks HD*, Labit E, Robbins H, Gowing K, Jaffer A, Kutluberk E, Arora R, Raredon MSB, Cao L, Swanson S, Jiang P, Hee O, Pope H, Workentine M, Todkar K, Sharma N, Bharadia S, Chockalingam, de Almeida LGN, Adam M, Niklason L, Potter SS, Seifert AW, Dufour A, Gabriel V, Rosin NL, Stewart R, Muench G, McCorkell R, Matyas J, Biernaskie J. Distinct fibro-immune signalling modulates skin regeneration in reindeer. Cell. 2022 Dec 8;185(25):4717-4736.e25.

Profiled by scientific journals and news outlets: Cell, CBC, CTV News, Global News

 

3.    Abbasi S*, Sinha S*, Labit E*, Rosin N, Yoon G, Rahmani W, Jaffer A, Sharma N, Hagner A, Shah P, Arora RK, Yoon J, Islam A, Uchida A, Chang C-K, Stratton JA, Scott W, Rossi FM, Underhill TM, Biernaskie J. (2020). Distinct regulatory programs control latent regenerative potential of dermal fibroblasts during wound healing. Cell Stem Cell, 27, 1-17. Featured in Cell Stem Cell Previews.

Profiled by multiple news outlets: UCalgary, CTV News, Technology Network, ScienceDaily.

 

4.    Shin W, Rosin N, Sparks H, Sinha S, Rahmani W, Sharma N, Workentine M, Abbasi S, Stratton JA, Biernaskie J. (2020) Dysfunction of hair follicle mesenchymal progenitors contributes to age-related hair loss. Developmental Cell, 53, 185–198.

 

5.    Rahmani W, Liu Y, Rosin N, Raharjo E, Yoon J, Stratton JA, Biernaskie J. (2018) Macrophages activate hair follicle stem cells and promote hair follicle regeneration in a CX3CR1 and TGFβ1 dependent manner. Journal of Investigative Dermatology, Apr 26. pii: S0022-202X(18)31888-8.

 

6.    Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, Driskell RR, Rosenthal N, Biernaskie J, Horsley V. (2021) Fibroblasts: origins, definitions, and functions in health and disease.  Cell, 184(15):3852-3872. 

 

Neural stem cells and glial cell biology

 

1.    Han S, Wilkinson GA, Okawa S, Faisal I, Adnani L, Dixit R,  Brooks M, Cortay M, Chinchalongporn V, Zinyk D, Li S, Gao G, Malik F, Touahri Y, Espinosa Angarica V, Raharjo E, Ilnytskyy Y Kim J-W, Wu W, Rahmani W, Kovalchuk I, Ai-wen Chan J, Gotz M, Kurrasch D, Castro DS, Dehay D, Swaroop A, Biernaskie J, del Sol A, Schuurmans C. (2021) Proneural genes define ground state rules to regulate lineage bias, neurogenic patterning and cortical folding. Neuron, 109(18):2847-2863.e11. 

 

2.    Rosin JM, Sinha S, Biernaskie J, Kurrasch DM.  (2021).  A Subpopulation of Embryonic Microglia Respond to Maternal Stress and Influence Nearby Neural Progenitors. Developmental Cell, S1534-5807(21)00244-6.

 

3.    Plemel JR*, Stratton JA*, Michaels NJ, Rawji KS, Zhang E, Sinha S, Baaklini CS, Dong Y, Ho M, Thorburn K, Friedman TN, Jawad S, Silva C, Caprariello AV, Hoghooghi V, Yue, J, Jaffer A, Lee K, Kerr BJ, Midha R, Stys PK, Biernaskie J**, Yong VW** (2020) Microglia restrict the accumulation of infiltrating macrophages following acute demyelination. Science Advances. 6: eaay6324. 

 

4.    Shin W, Alpaugh W, Hallihan LJ, Sinha S, Crowther E, Martin GR, Scheidl-Yee T, Yang X, Yoon G, Goldsmith T, Berger ND, de Almeida LG, Dufour A, Dobrinski I, Weinfeld M, Jirik FR, Biernaskie J. Pnkp is required for maintaining the integrity of progenitor cell populations in adult mice. Life Science Alliance. 4, e202000790.

 

5.    Shah P, Stratton JA, Abbasi S, Stykel M, Mayr KA, Koblinger K, Sharma S, Whelan P, Biernaskie J. (2018) Single cell transcriptomics and fate mapping of ependymal cells reveals an absence of neural stem cell function. Cell, 173(4): 1045-1057.

  

SARS-CoV-2

 

1.    Sinha S*, Rosin NL*, Arora R, Labit E, Jaffer A, Cao L, Franyutti RF, Nguyen A, de Almeida NG, Dufour A, Bromley A, McDonald B, Gillrie M, Fritzler M, Yipp B*, Biernaskie J*. (2022) Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19. Nature Medicine, 28(1):201-211. 

Featured in: Nature Rev Immunol, Calgary Herald, Healthing.ca, ANI, Ottawa Citizen

 

2.    Rahmani W, Chung H, Sinha S, Bui-Marinos MP, Arora R, Jaffer A, Corcoran JA, Biernaskie J*, Chun J*. (2022) Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids. iScience, 25(2):103818.