2022-2023 Publications

  1. Tung LW, Groppa E, Hesham Soliman H, Lin B , Chang C, Cheung CW, Ritso M, Guo D, Rempel L, Sinha S, Eisner C, Brassard  J, McNagny K, Biernaskie J, Rossi F. (2023) Spatiotemporal signaling underlies progressive vascular rarefaction in myocardial infarction. Nature Communications, in press.  [IF=17.7] 
  2. Rajan AM, Rosin NL, Labit E, Biernaskie J, Liao S, Huang P. (2023) Single-cell analysis reveals distinct fibroblast plasticity during tenocyte regeneration in zebrafish. Science Advances, 9:eadi5771. [IF=13.6]
  3. Arora R, Cao C, Kumar M, Sinha S, Chanda A, McNeil R, Samuel D, Arora RK, Matthews TW, Chandarana S, Hart R, Dort JC, Biernaskie J, Neri P, Hyrcza MD, Bose P. (2023) Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response. Nature Communications, 14:5029.  [IF=17.7]  Featured in: The Scientist
  4. Chitturi P, Shi-wen X, Abdi BA, Nguyen J, Carter DE,  Sinha S, Arora R, Biernaskie J, Stratton RJ,  Leask A. (2023) The Triptryium wilfordii derivative celastrol, a YAP inhibitor, has anti-fibrotic effects in systemic sclerosis. Annals of the Rheumatic Diseases, in press. [IF=28] 
  5. Kleeman SO, Thakir TM, Demestichas B, Mourikis N, Loiero D, Ferrer M, Bankier S, Riazat-Kesh YJRA, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida LGN, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren JLM, Ralser M, Kurth  F, Demechev V, Heywood T, Gao Q, Johannsson G, Koelzer VH, Walker BR, Meyer HV, Tobias Janowitz T. (2023) Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy. Cell Genomics, 3(8):100347. doi: 10.1016/j.xgen.2023.100347. [IF=17.7] 
  6. Nikolic A, Maule F, Bobyn A, Ellestad K, Paik S,  Marhon S, Mehdipour P, Lun X, Mallard C, Hay A, Johnston M, Gafuik C, Zemp F, Shen Y, Ninkovic N, Osz K, Labit E, Berger D, Brownsey D, Kelly J, Biernaskie J, Dirks P, Derksen D, Jones S, Senger D, Chan J, Mahoney D, De Carvalho D, Chen H-M, Gallo M. (2023) macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma. Nature Communications, 14:3062. doi: 10.1038/s41467-023-38919-2. [IF=17.7] 
  7. Yaqubi M, Groh AMR, Dorion MF, Afanasiev E, Luo JXX, Hashemi H, Sinha S, Kieran NW, Blain M, Cui QL, Biernaskie J, Srour M, Dudley R, Hall JA, Sonnen JA, Arbour N, Prat A, Stratton JA, Antel J, Healy LM. (2023). Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing. J Neuroinflammation, 20, 132. doi: 10.1186/s12974-023-02809-7. [IF=9.6] 
  8. Gillrie MR, Rosin N, Sinha S, Kang H, Farias R, Nguyen A, Volek K, Mah J, Mahe E, Fritzler MJ, Yipp BG, Biernaskie J. (2023). Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A). Front Immunol. 14:1125960. doi: 10.3389/fimmu.2023.1125960. [IF=7.3] 
  9. Sinha S*, Sparks HD*, Labit E, Robbins H, Gowing K, Jaffer A, Kutluberk E, Arora R, Brickman Raredon MS, Cao L, Swanson S, Jiang P,  Hee O, Pope H, Workentine M, Todkar K, Sharma N, Bharadia S, Chockalingam K, de Almeida LGN, Adam M, Niklason L, Potter S, Seifert AW, Dufour A, Gabriel V, Rosin NL, Stewart R, Muench G, McCorkell R, Matyas JR, Biernaskie J. (2022). Fibroblast ground states determine reparative inflammation and skin healing outcomes. Cell, 185, 4717–4736.  [IF=66.8]  https://doi.org/10.1016/j.cell.2022.11.004Featured in: Cell Leading Edge Preview, Nature Reviews Immunology, The Globe and Mail, CTV News, 770 News, CBC Eyeopener, Global News, BioWorld. Named ‘Best paper of 2022’ at 2023 American Burn Association Annual Scientific Meeting
  10. Sarden N, Sinha S, Potts KG, Pernet E, Hiroki CH, Hassanabad MF, Nguyen AP, Lou Y, Farias R, Winston BW, Bromley A, Snarr BD, Zucoloto AZ, Andonegui1 G,  Muruve DA, McDonald B, Sheppard DC, Mahoney DJ, Divangahi M, Rosin NL Biernaskie J, Yipp BG. (2022). A B1a–natural IgG–neutrophil axis is impaired in viral- and steroid-associated aspergillosis. Science Translational Medicine, 14, eabq66. [IF=18.0] DOI: 10.1126/scitranslmed.abq6682
  11. Kratofil RM, Shim, HB, Shim R, Lee WY, Labit E, Sinha S, Keenan CM, Surewaard BJG, Noh JY, Sun Y, Sharkey KA, Mack M, Biernaskie J, Deniset JF, and Kubes P. (2022) A monocyte-leptin-angiogenesis pathway critical for repair post-infection. Nature, 609: 166–173.  [IF=69.5] DOI: 10.1038/s41586-022-05044-x
  12. Chu T, Baral K, Labit E, Rosin N, Sinha S, Umansky D, Arora R, Cao L, Alzahrani S, Rancourt D, Biernaskie J, Midha R.  (2022) Comparison of human skin- and nerve-derived Schwann cells reveals many similarities and subtle genomic and functional differences. Glia, doi: 10.1002/glia.24242.  [IF=7.5]
  13. Sparks HD, Mandla S, Vizely K, Rosin N, Radisic M, Biernaskie J. (2022) Application of an instructive hydrogel accelerates re-epithelialization of xenografted human skin wounds.  Scientific Reports, 12:14233. doi: 10.1038/s41598-022-18204-w.
  14. Turk M, Biernaskie J, Mahoney DJ, Jenne C. (2022) Intravital Microscopy Techniques to Image Wound Healing in Mouse Skin. Methods Mol Biol 2440:165-180.
  15. Rahmani W, Chung H, Sinha S, Bui-Marinos MP, Arora R, Jaffer A, Corcoran, JA, Biernaskie J*, Chun J.*. (2022) Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids. iScience, 25(2):103818. [IF=4.5]
  16. Sinha S*, Rosin NL*, Arora R, Labit E, Jaffer A, Cao L, Franyutti RF, Nguyen A, de Almeida NG, Dufour A, Bromley A, McDonald B, Gillrie M, Fritzler M, Yipp B*, Biernaskie J*. (2022) Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19. Nature Medicine, 28(1):201-211. doi: 10.1038/s41591-021-01576-3. [IF= 53.4] | Featured in: Nature Rev Immunol, Calgary Herald, Healthing.ca, ANI, Calgary Sun, Ottawa Citizen | Voigt AL, Dardari R, Su L, Lara NLM, Sinha S, Jaffer A, Munyoki SK, Alpaugh WA, Dufour A, Biernaskie J, Orwig KE, Dobrinski I. (2022). Metabolic Transitions Define Spermatogonial Stem Cell Maturation. Human Reproduction, 37(9): 2095-2112. [IF=17.2]
  17. Krawetz RJ, Abubacker S, Leonard C, Masson AO, Shah S, Narendran N, Tailor P, Regmi SC, Labit E, Ninkovic N, Corpuz JM, Ito K, Underhill TM, Salo PT, Schmidt TA, Biernaskie J. (2022) Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration. NPJ Regenerative Medicine, 7(1):32. doi: 10.1038/s41536-022-00228-5. [IF=14.4]