Publications

Mizen, K., Woodman, J., Boysen, S. R., Wagg, C., Greco?Otto, P., Léguillette, R., & Roy, M. F. (2017). Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses. Journal of Veterinary Internal Medicine, 31(1), 164-169.

Corbeil, L. E., Morrissey, J. F., & Leguillette, R. (2016). Is Corynebacterium pseudotuberculosis infection (pigeon fever) in horses an emerging disease in western Canada?. The Canadian veterinary journal= La revue veterinaire canadienne, 57(10), 1062.

Looijen, M. G., New, D. J., Fischer, C. D., Dardari, R., Irwin, K. M., Berezowski, C. J., ... & Léguillette, R. (2016). Expression of T helper cell–associated inflammatory mediator mRNAs in cells of bronchoalveolar lavage fluid samples and oxygen concentration in arterial blood samples from healthy horses exposed to hyperbaric oxygen. American Journal of Veterinary Research, 77(10), 1148-1156.

Shields, E., Seiden-Long, I., Massie, S., Passante, S., & Leguillette, R. (2016). Analytical validation and establishment of reference intervals for a ‘high-sensitivity’cardiac troponin-T assay in horses. BMC veterinary research, 12(1), 104.

Léguillette, R., Steinmann, M., Bond, S. L., & Stanton, B. (2016). Tracheobronchoscopic Assessment of Exercise?Induced Pulmonary Hemorrhage and Airway Inflammation in Barrel Racing Horses. Journal of Veterinary Internal Medicine, 30(4), 1327-1332.

Couëtil, L. L., Cardwell, J. M., Gerber, V., Lavoie, J. P., Léguillette, R., & Richard, E. A. (2016). Inflammatory airway disease of horses—revised consensus statement. Journal of veterinary internal medicine, 30, 503-513.

Lewis, D., Scott, M., Fischer, C. D., Bond, S. L., & Léguillette, R. (2016). Feasibility for ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in horses. Veterinary Radiology & Ultrasound, 57(3), 299-305.

Woodman, J., Wagg, C. R., Boysen, S. R., Leguillette, R., Mizen, K., & Roy, M. F. (2015). Evaluation of coagulation via thromboelastography in healthy horses administered dexamethasone. The Canadian veterinary journal= La revue veterinaire canadienne, 56(12), 1271-1274.

Koblinger, K., Hecker, K., Nicol, J., Wasko, A., Fernandez, N., & Léguillette, R. (2014). Bronchial collapse during bronchoalveolar lavage in horses is an indicator of lung inflammation. Equine veterinary journal, 46(1), 50-55.

Fernandez, N. J., Hecker, K. G., Gilroy, C. V., Warren, A. L., & Léguillette, R. (2013). Reliability of 400?cell and 5?field leukocyte differential counts for equine bronchoalveolar lavage fluid. Veterinary clinical pathology, 42(1), 92-98.

Czerwinski, S. L., Lyon, A. W., Skorobohach, B., & Léguillette, R. (2012). Pharmacokinetic analysis of topical tobramycin in equine tears by automated immunoassay. BMC veterinary research, 8(1), 141.

 2012: “Comparison of cytokine mRNA expression in the bronchoalveolar lavage fluid of horses with Inflammatory Airway Disease and bronchoalveolar lavage mastocytosis or neutrophilia using REST software analysis” L. Beekman, T. Tohver, R. Léguillette. Journal of Veterinary Internal Medicine, 26 (1), p.153-161. Impact: 2.27

2011: “Endoscopic assessment of airway inflammation in horses”, K. Koblinger, J. Nicol, A. Wasko, K. McDonald, N. Logie, M. Weiss, R. Léguillette. Journal of Veterinary Internal Medicine, 25 (5), p.1118-1126. Impact: 2.27

• Selected as Most Clinically Relevant publications of the Year: Kester News Hour for the AAEP Convention 2011, Medicine Respiratory and Cardiovascular category.

2011: “Evaluation of suitable reference genes for gene expression studies in bronchoalveolar lavage cells from horses with Inflammatory Airway Disease”, L. Beekman, T. Tohver, R. Dardari, R. Léguillette. BMC Molecular Biology, 12 (5) (Highly accessed paper 3 weeks after publication). Impact: 3.19

 2011: “Evaluation of a risk-screening questionnaire to detect equine lung inflammation: results of a large field study”, A.J. Wasko, H.W. Barkema, J. Nicol, N. Fernandez, N. Logie, R. Léguillette. Equine Veterinary Journal 43 (2), p.145-152. Impact: 2.31

• Selected as Most Clinically Relevant publications of the Year: Kester News Hour for the AAEP Convention 2011, Medicine Respiratory and Cardiovascular category.

2010: “Dexamethasone and fluticasone significantly decrease airway hyperresponsiveness in horses with inflammatory airway disease (IAD)”, T. Tohver, D. New, J. Nicol, K. McDonald, N. Fernandez, R. Léguillette. Equine Veterinary Journal (Accepted, final review). Impact: 2.31

 2009: ‘Myosin, transgelin, and myosin light chain kinase: expression and function in asthma’, R. Léguillette, M. Laviolette, C. Bergeron, N. B. Zitouni, P. Kogut, J. Solway, L. Kashmar, Q. Hamid, A.-M. Lauzon. American Journal of Respiratory and Critical Care Medicine. 179 (3), p194-204. Impact: 10.69

 2009: Cover page of the American Journal of Respiratory and Critical Care Medicine. 179 (3). “Photomicrograph of an endobronchial biopsy sample from an individual with asthma, showing representative immunohistochemistry of SM22 expression.”

 2008: ‘Affinity for MgADP and force of unbinding from actin of myosin purified from tonic and phasic smooth muscle’, R. Léguillette, N. B. Zitouni, K. Govindaraju, M. Fong, A.-M. Lauzon. American Journal of Physiology: Cell Physiology. 295 (3), pC653-60. Impact: 4.13

 2008: “Molecular mechanics of smooth muscle contractile proteins in airway Hyperresponsiveness and asthma”, R. Léguillette, A.-M. Lauzon. Proceedings of the American Thoracic Association 5(1), p40-46.

2007: Pratique Veterinaire Equine: “Cardiovascular and respiratory congenital malformations in the foal and their effect on performance”, R. Léguillette.

2006: American Journal of Veterinary Research: 67(11) ‘Effects of bronchoalveolar lavages on lung mechanics in horses with clinical exacerbation of recurrent airway obstruction. R. Le?guillette, J.P. Lavoie.

2006: International Journal of Biochemistry and Cell Biology: 38(11), p1862-1874 ‘(+)Insert Smooth Muscle Myosin Heavy Chain (SM-B): From Single Molecule To Human. Low R., R. Le?guillette, and A.-M. Lauzon.

2005: American Journal of Physiology, Cell physiology: Vol.289, N. 5, pC1277-1285: ‘(+)Insert (SMB) Smooth Muscle Myosin Heavy Chain Isoform Expression in Human Tissues' R. Le?guillette, F.R. Gil, N. Zitouni, S. Lajoie-Kadoch, A. Sobieszek, A.M. Lauzon.

2004: American Journal of Respiratory Cell and Molecular Biology: Vol.30, N. 3, p326- 332: ‘Time course of airway mechanics of the (+)insert myosin isoform knockout mouse'. S. A.Tuck, K. Maghni, A. Poirier, G. J. Babu, M. Periasamy, J. H. Bates, R. Le?guillette, A. M. Lauzon.

2003: Veterinary Clinics of North America, Equine Practice: Vol.19, N. 1, p63-86: 'Recurrent airway obstruction: Heaves'. R. Le?guillette.

2003: Equine Veterinary Journal: Vol.35, N. 4, p419-424: 'Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction ('heaves')'. V. Picandet, R. Le?guillette, J-P. Lavoie

2002: Le Me?decin Ve?te?rinaire du Que?bec: Vol.32, N. 2, p79-80: 'E?tude des valeurs normales de cre?atinine sanguine chez les chevaux Quarter Horse'. E. Sergerie, R. Le?guillette.

2002: American Journal of Veterinary Research: Vol.63, N. 4, p579-585: 'Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction'. J.P. Lavoie, R. Le?guillette, L. Charrette, N. Sawyer, D.Guay, T. Murphy, K. Pasloske, G. Hickey

2002: American Journal of Veterinary Research: Vol.63, N. 3, p459-463: 'Effects of pentoxifylline on pulmonary function and results of cytologic examination of bronchoalveolar lavage fluid in horses with recurrent airway obstruction.' R. Le?guillette, C. Deseveaux, J.P. Lavoie.

2000: Equine Veterinary Journal: Vol.32, N. 5, p418-425: 'Equine proliferative enteropathy: A cause of weight loss, colic, diarrhea and hypoproteinaemia in foals on three breeding farms in Canada'. J.P. Lavoie, R. Drolet, D. Parsons, R. Le?guillette, R. Sauvageau, J. Shapiro, L. Houle, G. Halle?, and C.J. Gebhart

1998: Le Me?decin Ve?te?rinaire du Que?bec: Vol 28, N. 2, p87-90: 'Obstruction œsophagienne cause?e par un clou traite?e par œsophagostomie et nutrition ente?rale chez un cheval'. R. Le?guillette, J.P. Lavoie, M.F. Roy

2002: Equine Respiratory Diseases, Editor : P. Lekeux. Chapter: 'Foal Pneumonia' R. Le?guillette, M.F. Roy, J.P. Lavoie. Available online: International Veterinary Information Service, Ithaca NY, www.ivis.org.

2006 : American Journal of Respiratory and Critical Care Medicine, Poster discussion session, #606 pA770: ‘The protein expression of the smooth muscle myosin isoform SMB, MLCK, and SM22 is upregulated in asthmatic airways and may contribute to their hypercontrctility', R. Leguillette, C. Bergeron, M. Laviolette, A.M. Lauzon.

2005: Annual Scientific Meeting, Reseau en Sante Respiratoire du FRSQ. Oral Presentation: ‘Smooth muscle contractile proteins MLCK, myosin SMB and SM22 are overexpressed in asthmatic patients and alter smooth muscle mechanics in vitro.' #27.

2005: 13th Annual Meeting of the North East Smooth Muscle Society (NESM). Oral Presentation: ‘Faster rate of actin filament propulsion by tracheal smooth muscle myosin purified from an inbred rat model of airway hyperresponsiveness.' p9.

2005: The 12th International Congress of Biorheology (ICB) and the 5th International Conference on Clinical Hemorheology (ICCH), Chongqing, China. Oral presentation: ‘Molecular mechanics of tonic and phasic smooth muscle myosin in the latch-state‘

2005: American Journal of Respiratory and Critical Care Medicine, Poster discussion session, #A338: ‘Quantitative Smooth Muscle RNA Analysis of Asthmatic Human Bronchial Biopsies', R. Leguillette, M. Laviolette, A.M. Lauzon.

2005: American Journal of Respiratory and Critical Care Medicine, Poster, #A785: ‘Molecular Mechanics of Tonic and Phasic Smooth Muscle Myosin in the Latch State', R. Leguillette, N.B. Zitouni, K. Govindaraju, A.M. Lauzon.

2005: American Journal of Respiratory and Critical Care Medicine, Poster, #A504: ‘Myosin Regulatory Light Chain Phosphorylation in Hyperresponsive Airway Smooth Muscle', F.R. Gil, R. Leguillette, N.B. Zitouni, A.M. Lauzon.

2005: American Journal of Respiratory and Critical Care Medicine, Poster, #A784: ‘In Vitro Motility Assay of Purified Rat Tracheal Smooth Muscle Myosin', N.B. Zitouni, R. Leguillette, F.R. Gil, A. Sobieszek, A.M. Lauzon.

2005: 1st Annual McGill Biophysical Chemistry Symposium. Poster presentation: ‘Dephosphorylated smooth muscle myosin can attach to actin' R. Le?guillette, N.B. Zitouni, R. Govindaraju, A.M. Lauzon. p 8.

2004: 12th Annual Meeting of the North East Smooth Muscle Society (NESM). Oral Presentation: ‘ Molecular Mechanics of Smooth Muscle Myosin in Latch State' p9.

2004: American Journal of Respiratory and Critical Care Medicine, Poster, #A878: 'Quantitative RNA analysis of the fast smooth muscle myosin heavy chain isoform in human airways', R. Le?guillette, S. Lajoie, A.M. Lauzon.

2004: 4th International Young Investigators' Symposium on Smooth Muscle, Epithelium, and Airway Inflamation, Poster presentation: 'Quantitative RNA analysis of the fast smooth muscle myosin heavy chain isoform in human airways', R. Le?guillette, S. Lajoie, A.M. Lauzon. p10.

2004: 4th Annual McGill Biomedical Graduate Conference, Poster presentation: ‘Differential MgATP affinity of tonic and phasic smooth muscle myosin in the in vitro motility assay', R. Le?guillette, N.B. Zitouni, A.M. Lauzon. p29.

2004: 15th Annual McGill Respiratory Research Day, Oral presentation: ‘Molecular mechanics of smooth muscle in the latch state', p4.

2004: Biophysical Society 48th Annual Meeting, Oral presentation: ‘Differential MgADP affinity of tonic and phasic smooth muscle myosin in the in vitro motility assay' R. Le?guillette, N.B. Zitouni, A.M. Lauzon. #905-Plat.

2004: Veterinary Comparative Respiratory Society, 22th symposium, Oral presentation: 'Molecular mechanics of airway smooth muscle', p52 R. Le?guillette, A.M. Lauzon.

2003: American Journal of Respiratory and Critical Care Medicine, Poster, #A878: 'Combined effects of phosphorylation and MgADP on Smooth muscle cross-bridge cycling' R. Le?guillette, N.B. Zitouni, D. Ludvig, A.M. Lauzon.

2003: 3rd International Young Investigators' Symposium on Smooth Muscle, Epithelium, and Airway Inflamation, Poster presentation: ‘Combined effects of phosphorylation and MgADP on smooth muscle cross-bridge cycling' p10.

2003: 14th Annual McGill Respiratory Research Day, Oral presentation: ‘Combined effects of phosphorylation and MgADP on tonic and phasic smooth muscle myosin' p7.

2003: 3rd Annual McGill Biomedical Graduate Conference, Poster presentation: ‘Combined effects of phosphorylation and MgADP on smooth muscle cross-bridge cycling' p28. -2002: Veterinary Comparative Respiratory Society, 20th symposium, Poster: 'Effects of bronchoalveolar lavage on the respiratory mechanics of horses with heaves'. R. Le?guillette, J-P Lavoie.

2000: American Journal of Respiratory and Critical Care Medicine, Poster, #A185: 'Comparison of Dexamethasone and the LTD4 Receptor Antagonist L-708,738 in an Equine COPD Model.' Lavoie, J. P., R. Le?guillette, L. Charette, N. Sawyer, T. Murphy, K. Pasloske, and G. Hickey.

1998: American College of Veterinary internal Medicine, Poster #231: 'Effects of pentoxifylline in horses with chronic obstructive pulmonary disease (COPD)'. R. Le?guillette, et J.P. Lavoie.

1998: Journe?e de l'Association des Ve?te?rinaires E?quins Francais, "Diagnostic en pratique e?quine: actualite?s", pp. 67-79: 'Examens diagnostiques du tractus digestif lors de colique.' A. Vrins, R. Le?guillette, A. Lannevschi.

1998: Journe?e de l'Association des Ve?te?rinaires E?quins Francais, "Diagnostic en pratique e?quine: actualite?s", pp. 82-86: 'Investigations cliniques des proble?mes de maldigestion/malabsorption' A. Vrins, R. Le?guillette, J. Lapointe.